Boudalia, Sofiane and Bousbia, Aissam and Boumaaza, Boualem and Oudir, Malha and Canivenc Lavier, Marie Chantal (2020) Relationship between endocrine disruptors and obesity with a focus on bisphenol A: a narrative review. BioImpacts, 11 (4). pp. 289-300. ISSN 2228-5660
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Abstract
Introduction: Scientific data suggest that early exposure to endocrine-disrupting chemicals (EDCs) affect -repro, -neuro, -metabolic systems, to which are added other notions such as mixtures, window and duration of exposure, trans-generational effects, and epigenetic mechanisms.
Methods: In the present narrative review, we studied the relationship between exposure to EDCs with the appearance and development of obesity.
Results: Exposure to EDCs like Bisphenol A during the early stages of development has been shown to lead to weight gain and obesity. EDCs can interfere with endocrine signaling, affect adipocytes differentiation and endocrine function and disrupt metabolic processes, especially if exposure occurs at very low doses, in the mixture, during early development stages for several generations.
Conclusion: Exposure to EDCs is positively associated with obesity development. Moreover, the use of integrative approaches which mimicking environmental conditions are necessary and recommended to evaluate EDCs' effects in future studies.
Item Type: | Article |
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Subjects: | Librbary Digital > Medical Science |
Depositing User: | Unnamed user with email support@librbarydigit.com |
Date Deposited: | 03 Apr 2023 08:51 |
Last Modified: | 12 Aug 2024 12:02 |
URI: | http://info.openarchivelibrary.com/id/eprint/384 |