Gas Chromatography/Mass Spectrography (GC/MS) Analysis and Biological Properties of Probiotic Fermented Solenostemma argel

Solenostemma argel (S. argel) is an important medicinal plant in Egypt and Sudan, with antitumor effects. This study objective to elucidate the chemometric profile and antitumor properties of S. argel extract and the effect of fermentation on its properties. S. argel was fermented by two probiotic strains Lactobacillus rhamnosus and Lactobacillus acidophilus. While fermentation reduced total phenolics, and total flavonoid contents as well as DPPH radical scavenging activity, it enhanced antitumor activity on Ehrlich ascites carcinoma cell. The GC/MS analysis of fermented and non-fermented S. argel revealed the formation of new compounds of known antitumor activity.