Laredo, Fabio and Plebanski, Julia and Tedeschi, Andrea (2019) Pericytes: Problems and Promises for CNS Repair. Frontiers in Cellular Neuroscience, 13. ISSN 1662-5102
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Abstract
Microvascular complications are often associated with slow and progressive damage of various organs. Pericytes are multi-functional mural cells of the microcirculation that control blood flow, vascular permeability and homeostasis. Whereas accumulating evidence suggests that these cells are also implicated in a variety of diseases, pericytes represent promising targets that can be manipulated for therapeutic gain. Here, we review the role of pericytes in angiogenesis, blood-brain barrier (BBB) function, neuroinflammation, tissue fibrosis, axon regeneration failure, and neurodegeneration. In addition, we outline strategies altering pericyte behavior to point out problems and promises for axon regeneration and central nervous system (CNS) repair following injury or disease.
Item Type: | Article |
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Subjects: | Librbary Digital > Medical Science |
Depositing User: | Unnamed user with email support@librbarydigit.com |
Date Deposited: | 25 May 2023 11:45 |
Last Modified: | 05 Sep 2024 11:46 |
URI: | http://info.openarchivelibrary.com/id/eprint/749 |