Dubes, Sandra and Favereaux, Alexandre and Thoumine, Olivier and Letellier, Mathieu (2019) miRNA-Dependent Control of Homeostatic Plasticity in Neurons. Frontiers in Cellular Neuroscience, 13. ISSN 1662-5102
pubmed-zip/versions/1/package-entries/fncel-13-00536/fncel-13-00536.pdf - Published Version
Download (751kB)
Abstract
Homeostatic plasticity is a form of plasticity in which neurons compensate for changes in neuronal activity through the control of key physiological parameters such as the number and the strength of their synaptic inputs and intrinsic excitability. Recent studies revealed that miRNAs, which are small non-coding RNAs repressing mRNA translation, participate in this process by controlling the translation of multiple effectors such as glutamate transporters, receptors, signaling molecules and voltage-gated ion channels. In this review, we present and discuss the role of miRNAs in both cell-wide and compartmentalized forms of homeostatic plasticity as well as their implication in pathological processes associated with homeostatic failure.
Item Type: | Article |
---|---|
Subjects: | Librbary Digital > Medical Science |
Depositing User: | Unnamed user with email support@librbarydigit.com |
Date Deposited: | 26 May 2023 07:02 |
Last Modified: | 12 Sep 2024 04:57 |
URI: | http://info.openarchivelibrary.com/id/eprint/751 |